Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.58 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.42 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7377905 | 0.85 | PDE3B (0.64) | PDE3BPDE3AMEN1KMT2A | |
| SCHEMBL7387266 | 0.81 | MEN1 (0.59) | PDE3BPDE3AHSPD1HSPE1MAPK1 | |
| SCHEMBL7383419 | 0.80 | PDE3B (0.70) | PDE3BPDE3A | |
| SCHEMBL7383915 | 0.79 | PDE3B (0.58) | PDE3BPDE3ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7378034 | 0.79 | PDE3B (0.55) | PDE3BPDE3APPARGPPARA | |
| SCHEMBL7382397 | 0.77 | PDE3B (0.53) | PDE3BPDE3A | |
| SCHEMBL7382885 | 0.76 | PDE3B (0.72) | PDE3BPDE3A | |
| SCHEMBL7386282 | 0.76 | PDE3B (0.72) | PDE3BPDE3A | |
| SCHEMBL7384334 | 0.76 | PDE3B (0.64) | PDE3BPDE3ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7388786 | 0.76 | PDE3B (0.51) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5010086-A | Enzyme inhibitor for treating congestive heart failure or hypertension in mammals | STERLING DRUG INC. (US) | 1991-04-23 | — | — | US | disclosed |
| US-4963561-A | Phosphodiesterase inhibitors | STERLING DRUG INC. (US) | 1990-10-16 | — | — | US | disclosed |