Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.56 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.56 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.56 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6754913 | 0.96 | PDK1 (0.60) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL7385259 | 0.84 | PDK1 (0.61) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL7669258 | 0.83 | NOTUM (0.57) | LMNAMAPTBRD4HSD17B10MPO | |
| SCHEMBL5638046 | 0.83 | HSD17B10 (0.49) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL3657122 | 0.82 | HSD17B10 (0.48) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL24011118 | 0.82 | LMNA (0.71) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL18109844 | 0.81 | ABHD6 (0.53) | PDK1PDK2PDK3PDK4BRD4 | |
| SCHEMBL6757671 | 0.80 | PDK1 (0.66) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL6752845 | 0.80 | NOTUM (0.59) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL4691685 | 0.79 | NOTUM (0.55) | PDK1PDK2PDK3PDK4BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369221-B1 | Thiazolobenzoheterocycles, preparation and medicines containing same | AVENTIS PHARMA S.A. (FR) | 2002-04-09 | — | — | US | disclosed |