Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.46 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.46 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.46 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.46 |
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 15/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8696748 | 1.00 | KDM4E (0.46) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7385367 | 0.88 | KDM4E (0.57) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| Fumaric Acid SCHEMBL27619908 | 0.82 | PIM2 (0.54) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| Maleic Acid SCHEMBL8697078 | 0.77 | TRPV1 (0.45) | PTPN11KCNH2 | |
| Fumaric Acid SCHEMBL8697083 | 0.77 | TRPV1 (0.45) | PTPN11KCNH2 | |
| SCHEMBL7384813 | 0.74 | KDM4E (0.48) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| Fumaric Acid SCHEMBL8699041 | 0.74 | PTPN11 (0.47) | PTPN11 | |
| Maleic Acid SCHEMBL8699032 | 0.74 | PTPN11 (0.47) | PTPN11 | |
| SCHEMBL31015127 | 0.74 | KDM4E (0.53) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4691863 | 0.72 | CNR1 (0.48) | KDM4EMEN1ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723611-A | Heteroarylpiperidines | SANOFI (FR) | 1998-03-03 | — | — | US | disclosed |
| US-5502063-A | 1-halopyridin-4-amino-4-alkylpiperidines | SANOFI (FR) | 1996-03-26 | — | — | US | disclosed |