Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11054495 | 0.87 | NPC1 (0.45) | MAPTGAAHTTPDE3BPDE3A | |
| SCHEMBL7384614 | 0.86 | PDE3B (0.47) | MAPTGAAHTTPDE3BPDE3A | |
| SCHEMBL7383615 | 0.85 | PDE3B (0.46) | MAPTGAAPDE3BPDE3AKMT2A | |
| SCHEMBL7381645 | 0.83 | PDE3B (0.44) | MAPTGAAPDE3BPDE3AL3MBTL1 | |
| SCHEMBL7384727 | 0.83 | PDE3B (0.62) | MAPTPDE3BPDE3AKMT2AKDM4E | |
| SCHEMBL10682046 | 0.83 | MAPT (0.48) | MAPTGAAHTTNPC1KMT2A | |
| SCHEMBL10682462 | 0.81 | MAPT (0.53) | MAPTGAAHTTNPC1KMT2A | |
| SCHEMBL10677653 | 0.81 | UCHL1 (0.53) | MAPTGAAHTTNPC1L3MBTL1 | |
| SCHEMBL7382511 | 0.81 | PDE3B (0.43) | MAPTGAAHTTPDE3BPDE3A | |
| SCHEMBL10679788 | 0.81 | MAPT (0.49) | MAPTGAAHTTNPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428045-A | 5-acyl-2-(1H)-pyridinoes | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-06-27 | — | — | US | disclosed |
| US-5118696-A | 5-Acyl-2-(1H)-pyridinones useful for treating cardiac failure | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4992452-A | Certain 5-acyl-2-(1H)-pyridinones useful in treating cardiac failure | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4853395-A | Certain 3-carboxylate or 3-carbamyl-5-acyl-2-(1H)-pyridinones having cardiotonic properties | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-08-01 | — | — | US | disclosed |
| US-4769380-A | Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-09-06 | — | — | US | disclosed |
| US-4731371-A | Certain 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles which are useful as cardiotonic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-15 | — | — | US | disclosed |
| EP-0124090-B1 | 5-ACYL-2-(1H)-PYRIDINONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-01 | — | — | EP | disclosed |
| EP-0124090-A1 | 5-Acyl-2-(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-11-07 | — | — | EP | disclosed |