Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10677717 | 0.88 | ALDH1A1 (0.44) | MAPTGAAHTTRAB9AKMT2A | |
| SCHEMBL10677653 | 0.86 | UCHL1 (0.53) | MAPTGAAHTTNPC1NPSR1 | |
| SCHEMBL10682462 | 0.86 | MAPT (0.53) | MAPTGAAHTTNPC1NPSR1 | |
| SCHEMBL10679716 | 0.85 | ALDH1A1 (0.52) | MAPTGAAHTTNPC1RAB9A | |
| SCHEMBL10679788 | 0.85 | MAPT (0.49) | MAPTGAAHTTNPC1NPSR1 | |
| SCHEMBL10678457 | 0.84 | LMNA (0.40) | MAPTGAAHTTNPC1RAB9A | |
| SCHEMBL7385630 | 0.83 | MAPT (0.45) | MAPTGAAHTTNPC1NPSR1 | |
| SCHEMBL10681806 | 0.81 | PDE3B (0.55) | MAPTNPSR1KMT2AALDH1A1LMNA | |
| SCHEMBL10683064 | 0.80 | NPC1 (0.50) | MAPTGAAHTTNPC1NPSR1 | |
| SCHEMBL10680809 | 0.76 | DRD2 (0.36) | GAAKMT2ALMNAKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4769380-A | Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-09-06 | — | — | US | disclosed |