Carbazole

Carbazole

SCHEMBL738564

N[C@@H](CS)C(=O)O.O=S(=O)(O)O.c1ccc2c(c1)[nH]c1ccccc12

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Carbazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 2/20 0.47
SLC7A11 Q9UPY5 1/20 0.47
KDM4E B2RXH2 2/20 0.47
MEN1 O00255 1/20 0.47
LMNA P02545 1/20 0.47
MPO P05164 1/20 0.47
MAPT P10636 1/20 0.47
TSHR P16473 1/20 0.47
BLM P54132 1/20 0.47
PMP22 Q01453 1/20 0.47
KMT2A Q03164 1/20 0.47
HIF1A Q16665 1/20 0.47
ALDH1A1 P00352 2/20 0.41
FOLH1 Q04609 1/20 0.41
GPR3 P46089 1/20 0.41
HSD17B10 Q99714 1/20 0.41
PDPK1 O15530 1/20 0.40
GRIA1 P42261 2/20 0.40
GRIA2 P42262 2/20 0.40
GRIA3 P42263 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Carbazole SCHEMBL7710915 1.00 PTGS1 (0.47) PTGS1SLC7A11KDM4EMEN1LMNA
Carbazole SCHEMBL450294 0.94 PTGS1 (0.53) PTGS1SLC7A11KDM4EMEN1LMNA
Carbazole SCHEMBL3393214 0.94 PTGS1 (0.53) PTGS1SLC7A11KDM4EMEN1LMNA
Carbazole SCHEMBL28207216 0.92 PTGS1 (0.52) PTGS1SLC7A11KDM4EMEN1LMNA
Carbazole SCHEMBL9632048 0.80 ALDH1A1 (0.45) KDM4EMEN1LMNAMAPTBLM
Cysteine SCHEMBL28269485 0.80 PTGS1 (0.55) PTGS1SLC7A11GRIA2ALPIPKM
Cysteine SCHEMBL29009435 0.79 PTGS1 (0.70) PTGS1SLC7A11BLMPMP22KMT2A
Cysteine SCHEMBL431234 0.77 PTGS1 (0.80) PTGS1SLC7A11TSHRBLMPMP22
Cysteine SCHEMBL11127430 0.77 PTGS1 (0.80) PTGS1SLC7A11TSHRBLMPMP22
Carbazole SCHEMBL10650068 0.77 ALDH1A1 (0.70) KDM4EMEN1LMNAMAPTBLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4051314-A FROM FUNGUS OF CLASS BASIDIOMYCETES, ANTICANCER AGENTS KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JA) 1977-09-27 US claimed
CN-106062188-B The L-arabinose isomerase variant of activity of conversion with raising and the method for producing D-Tag using the variant CJ CHEILJEDANG CORP. (KR) 2019-11-08 CN disclosed
EP-3115453-B1 L-ARABINOSE ISOMERASE VARIANT FOR PRODUCING D-TAGATOSE CJ CHEILJEDANG CORP (KR) 2018-06-27 EP disclosed
US-9896705-B2 L-arabinose isomerase variants with improved conversion activity and method for production of D-tagatose using them CJ CHEILJEDANG CORPORATION (KR) 2018-02-20 US disclosed
EP-2834354-B1 IMPROVED GALACTOSE ISOMERASES AND USE THEREOF IN THE PRODUCTION OF TAGATOSE NUTRILAB N V (BE) 2017-08-16 EP disclosed
US-20170137856-A1 L-arabinose Isomerase Variants with Improved Conversion Activity and Method for Production of D-tagatose Using them CJ CHEILJEDANG CORPORATION (KR) 2017-05-18 US disclosed
US-9593321-B2 L-arabinose isomerase variants with improved conversion activity and method for production of D-tagatose using them CJ CHEILJEDANG CORPORATION (KR) 2017-03-14 US disclosed
EP-3115453-A1 L-ARABINOSE ISOMERASE VARIANT HAVING IMPROVED CONVERSION ACTIVITY AND METHOD FOR PRODUCING D-TAGATOSE USING SAME CJ Cheiljedang Corporation (KR) 2017-01-11 EP disclosed
US-20160333335-A1 L-arabinose Isomerase Variants with Improved Conversion Activity and Method for Production of D-tagatose Using them CJ CHEILJEDANG CORPORATION (KR) 2016-11-17 US disclosed
CN-106062188-A L-arabinose isomerase variant having improved conversion activity and method for producing D-tagatose using same CJ第制糖株式会社 2016-10-26 CN disclosed
US-4347316-A GLUCOSE ISOMERASE IMMOBILIZED ON A GLUTARALDEHYDE-CROSSLINKED AROMATIC OLEFIN-BASED POLYMER MODIFIED BY N-METHYLOLACRYLAMIDE AND AN AMINE TORAY INDUSTRIES, INC. (JP) 1982-08-31 US disclosed
US-4275156-A ACRYLAMIDOMETHYLATED MONOVINYL AROMATIC POLYMER SUBSTRATE TORAY INDUSTRIES, INC. (JP) 1981-06-23 US disclosed
US-4255521-A HOMOGENIZING, PRESSURIZATION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1981-03-10 US disclosed
US-4247642-A Enzyme immobilization with pullulan gel SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1981-01-27 US disclosed
US-4239854-A HAVING CARBOXYMETHYL GROUPS AND AMINO GROUPS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1980-12-16 US disclosed
EP-0015367-A2 Immobilized glucose isomerase, process for preparing it and process for preparing fructose from glucose TORAY INDUSTRIES, INC. (JP) 1980-09-17 EP disclosed
US-4170696-A PHENOL-FORMALDEHYDE OR CROSSLINKED POLYSTYRENE WITH DIETHYLAMINOETHYL GROUPS, ION EXCHANGE RESINS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1979-10-09 US disclosed
US-4138292-A ENZYMES OR MICROORGANISMS IN A SULFATED POLYSACCHARIDE GEL TANABE SEIYAKU CO., LTD. (JP) 1979-02-06 US disclosed
US-4086138-A CULTURING CORYNEBACTERIUM AEROBICALLY NIPPON OIL COMPANY, LTD. (JA) 1978-04-25 US disclosed
US-4051314-A FROM FUNGUS OF CLASS BASIDIOMYCETES, ANTICANCER AGENTS KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JA) 1977-09-27 US disclosed