Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 10/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | ITGAV | P06756 | 1/20 | 0.44 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.44 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7386330 | 0.90 | EPHX2 (0.43) | EPHX2ITGB3ITGA2B | |
| SCHEMBL7384204 | 0.85 | ITGB3 (0.67) | ITGB3ITGA2BITGAVITGB5ITGB6 | |
| SCHEMBL7384441 | 0.84 | EPHX2 (0.49) | EPHX2ITGB3ITGA2BALDH1A1HPGD | |
| SCHEMBL9386349 | 0.82 | ITGB3 (0.43) | EPHX2ITGB3ITGA2BITGAVITGB5 | |
| SCHEMBL7385682 | 0.81 | ITGB3 (0.73) | EPHX2ITGB3ITGA2BCCR3THRB | |
| SCHEMBL7380918 | 0.81 | ITGB3 (0.60) | ITGB3ITGA2BITGAVITGB5ITGB6 | |
| SCHEMBL9293684 | 0.81 | TSHR (0.41) | EPHX2KMT2A | |
| SCHEMBL7387828 | 0.80 | EPHX2 (0.37) | EPHX2ITGB3ITGA2BALDH1A1HPGD | |
| SCHEMBL7383847 | 0.80 | EPHX2 (0.57) | EPHX2ITGB3ITGA2BCCR3 | |
| SCHEMBL7388376 | 0.80 | ITGB3 (0.59) | ITGB3ITGA2BITGAVITGB5ITGB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5344837-A | Platelet aggregation inhibitors | G.D. SEARLE & CO. (US) | 1994-09-06 | — | — | US | claimed |
| WO-1994001396-A1 | PHENYL AMIDINE UREA DERIVATIVES AS PLATELET AGGREGATION INHIBITORS | G.D. SEARLE & CO. (US) | 1994-01-20 | — | — | WO | claimed |
| US-5272162-A | Platelet aggregation inhibitors | G. D. SEARLE & CO. (US) | 1993-12-21 | — | — | US | claimed |
| US-5344837-A | Platelet aggregation inhibitors | G.D. SEARLE & CO. (US) | 1994-09-06 | — | — | US | disclosed |
| WO-1994001396-A1 | PHENYL AMIDINE UREA DERIVATIVES AS PLATELET AGGREGATION INHIBITORS | G.D. SEARLE & CO. (US) | 1994-01-20 | — | — | WO | disclosed |
| US-5272162-A | Platelet aggregation inhibitors | G. D. SEARLE & CO. (US) | 1993-12-21 | — | — | US | disclosed |