Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9389734 | 0.90 | KMT2A (0.45) | TSHRPOLBKMT2AATML3MBTL1 | |
| SCHEMBL7386038 | 0.89 | TSHR (0.42) | TSHRPOLB | |
| SCHEMBL7386056 | 0.87 | CTSG (0.52) | — | |
| SCHEMBL9293684 | 0.86 | TSHR (0.41) | TSHRPOLBKMT2ALMNAEPHX2 | |
| SCHEMBL9389954 | 0.85 | TSHR (0.40) | TSHRPOLBKMT2ALMNAEPHX2 | |
| SCHEMBL7388722 | 0.83 | HDAC1 (0.54) | — | |
| SCHEMBL7386158 | 0.81 | ALDH1A1 (0.45) | POLB | |
| SCHEMBL7388171 | 0.81 | LPAR1 (0.48) | — | |
| SCHEMBL7387879 | 0.80 | KMT2A (0.48) | POLBKMT2A | |
| SCHEMBL7387501 | 0.79 | CYP4Z1 (0.48) | POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994001396-A1 | PHENYL AMIDINE UREA DERIVATIVES AS PLATELET AGGREGATION INHIBITORS | G.D. SEARLE & CO. (US) | 1994-01-20 | — | — | WO | claimed |
| US-5272162-A | Platelet aggregation inhibitors | G. D. SEARLE & CO. (US) | 1993-12-21 | — | — | US | claimed |
| US-5344837-A | Platelet aggregation inhibitors | G.D. SEARLE & CO. (US) | 1994-09-06 | — | — | US | disclosed |
| WO-1994001396-A1 | PHENYL AMIDINE UREA DERIVATIVES AS PLATELET AGGREGATION INHIBITORS | G.D. SEARLE & CO. (US) | 1994-01-20 | — | — | WO | disclosed |
| US-5272162-A | Platelet aggregation inhibitors | G. D. SEARLE & CO. (US) | 1993-12-21 | — | — | US | disclosed |