Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.46 |
| ▸ | LIPE | Q05469 | 2/20 | 0.45 |
| ▸ | LSS | P48449 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.43 |
| ▸ | F10 | P00742 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7387646 | 0.86 | SIGMAR1 (0.51) | SIGMAR1ITGB3ITGA2BLIPEPRSS1 | |
| SCHEMBL7385957 | 0.84 | ITGB3 (0.47) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7388887 | 0.82 | LMNA (0.47) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7387996 | 0.82 | SIGMAR1 (0.49) | SIGMAR1ITGB3ITGA2BLSS | |
| SCHEMBL7388450 | 0.81 | KMT2A (0.46) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7068862 | 0.81 | GRM2 (0.57) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7392348 | 0.81 | ITGB3 (0.46) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7387212 | 0.81 | ITGB3 (0.46) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL7388576 | 0.80 | FABP6 (0.46) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7385750 | 0.80 | SIGMAR1 (0.54) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1281451-A | Benzamidine derivatives | MERCK PATENT GMBH (DE) | 2001-01-24 | — | — | CN | disclosed |
| EP-1056743-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999031092-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |