Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.51 |
| ▸ | LIPE | Q05469 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.43 |
| ▸ | F10 | P00742 | 3/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27541054 | 0.89 | F10 (0.44) | SIGMAR1ITGB3ITGA2BF10PRSS1 | |
| SCHEMBL7386103 | 0.86 | SIGMAR1 (0.52) | SIGMAR1LIPEITGB3ITGA2BF10 | |
| SCHEMBL7383582 | 0.86 | ITGB3 (0.47) | SIGMAR1ITGB3ITGA2BF10PRSS1 | |
| SCHEMBL7392421 | 0.86 | F10 (0.50) | SIGMAR1ITGB3ITGA2BF10PRSS1 | |
| SCHEMBL7389682 | 0.86 | LIPE (0.44) | SIGMAR1LIPEITGB3ITGA2BF10 | |
| SCHEMBL7385817 | 0.85 | POLB (0.47) | SIGMAR1ITGB3ITGA2BF10PRSS1 | |
| SCHEMBL7387830 | 0.84 | F10 (0.45) | SIGMAR1ITGB3ITGA2BF10PRSS1 | |
| SCHEMBL7386928 | 0.83 | F10 (0.44) | SIGMAR1HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL7386142 | 0.83 | ITGB3 (0.42) | SIGMAR1ITGB3ITGA2BF10PRSS1 | |
| SCHEMBL7387792 | 0.83 | F10 (0.46) | SIGMAR1ITGB3ITGA2BF10PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1281451-A | Benzamidine derivatives | MERCK PATENT GMBH (DE) | 2001-01-24 | — | — | CN | disclosed |
| EP-1056743-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999031092-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |