Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 19/20 | 0.47 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8699032 | 1.00 | PTPN11 (0.47) | PTPN11PANK3 | |
| SCHEMBL7391400 | 0.88 | PTPN11 (0.53) | PTPN11PANK3 | |
| Maleic Acid SCHEMBL8697078 | 0.81 | TRPV1 (0.45) | PTPN11 | |
| Fumaric Acid SCHEMBL8697083 | 0.81 | TRPV1 (0.45) | PTPN11 | |
| SCHEMBL7386664 | 0.75 | PANK3 (0.48) | PTPN11PANK3 | |
| Maleic Acid SCHEMBL8696748 | 0.74 | KDM4E (0.46) | PTPN11 | |
| Fumaric Acid SCHEMBL8696754 | 0.74 | KDM4E (0.46) | PTPN11 | |
| SCHEMBL15260451 | 0.72 | PANK3 (0.46) | PTPN11PANK3 | |
| SCHEMBL2228019 | 0.72 | PANK3 (0.58) | PANK3 | |
| SCHEMBL20425052 | 0.71 | PANK3 (0.60) | PTPN11PANK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5595994-A | 1-Halopyrazin- and 1-halopyrimidin-4-amino-4-alkylpiperidines | SANOFI (FR) | 1997-01-21 | — | — | US | claimed |
| US-5723611-A | Heteroarylpiperidines | SANOFI (FR) | 1998-03-03 | — | — | US | disclosed |
| US-5595994-A | 1-Halopyrazin- and 1-halopyrimidin-4-amino-4-alkylpiperidines | SANOFI (FR) | 1997-01-21 | — | — | US | disclosed |
| US-5502063-A | 1-halopyridin-4-amino-4-alkylpiperidines | SANOFI (FR) | 1996-03-26 | — | — | US | disclosed |