Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7384198 | 0.81 | KEAP1 (0.52) | TP53ALDH1A1POLBMAPT | |
| SCHEMBL4917411 | 0.77 | STAT3 (0.53) | TP53ALDH1A1LMNAMAPTCYP3A4 | |
| SCHEMBL7314095 | 0.76 | MMP1 (0.48) | TP53LMNAMAPTCYP2C9HSD17B10 | |
| SCHEMBL4927290 | 0.76 | SIRT2 (0.48) | TP53ALDH1A1POLBLMNAMAPT | |
| SCHEMBL6465065 | 0.75 | TP53 (0.54) | TP53ALDH1A1POLBLMNAMAPT | |
| SCHEMBL4918537 | 0.74 | TP53 (0.50) | TP53ALDH1A1POLBLMNAMAPT | |
| SCHEMBL4928804 | 0.73 | MAPK1 (0.43) | TP53ALDH1A1POLBLMNAMAPT | |
| SCHEMBL8752627 | 0.73 | KMT2A (0.56) | ALDH1A1POLBGAAF2NPC1 | |
| SCHEMBL1858294 | 0.73 | KMT2A (0.47) | TP53ALDH1A1LMNAMAPTF2 | |
| SCHEMBL22670302 | 0.72 | CYP3A4 (0.42) | ALDH1A1LMNACYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003751-A1 | HYDROXAMIC ACID SUBSTITUTED FUSED HETEROCYCLIC METALLOPROTEINASE INHIBITORS | AMGEN INC. (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999006410-A1 | HYDROXAMIC ACID SUBSTITUTED FUSED HETEROCYCLIC METALLOPROTEINASE INHIBITORS | AMGEN INC. (US) | 1999-02-11 | — | — | WO | disclosed |