Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 9/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7387 | 0.85 | NR1I2 (0.35) | RAB9ATDP1L3MBTL1BRD4SMN1; SMN2 | |
| SCHEMBL6652 | 0.83 | MEN1 (0.38) | MEN1KMT2AMTNR1AMTNR1BHPGD | |
| SCHEMBL6697 | 0.82 | MTNR1A (0.40) | MEN1KMT2AMTNR1AMTNR1BHPGD | |
| SCHEMBL6651 | 0.74 | MAPT (0.41) | MEN1KMT2AMTNR1AMTNR1BHPGD | |
| SCHEMBL11802 | 0.74 | CYP1A2 (0.33) | RAB9AHTTTDP1SMN1; SMN2MAPT | |
| SCHEMBL6943 | 0.72 | EPHX1 (0.35) | RAB9AL3MBTL1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2087 | 0.72 | EPHX1 (0.35) | RAB9AL3MBTL1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2762295 | 0.72 | FPR2 (0.40) | MEN1KMT2AHPGDRAB9AHTT | |
| SCHEMBL6814 | 0.71 | CYP1A2 (0.31) | TDP1 | |
| SCHEMBL1307 | 0.70 | EPHX1 (0.41) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |