Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342093 | 1.00 | BDKRB2 (0.45) | BDKRB2POLBALOX5AGTR2NPC1 | |
| SCHEMBL7387119 | 0.90 | POLB (0.45) | BDKRB2POLBALOX5ALDH1A1NPSR1 | |
| SCHEMBL2299502 | 0.89 | NPC1 (0.46) | POLBAGTR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7338874 | 0.87 | MCL1 (0.47) | POLBAGTR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7338869 | 0.87 | MCL1 (0.47) | POLBAGTR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7346785 | 0.86 | AGTR2 (0.46) | POLBAGTR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2437881 | 0.81 | MCL1 (0.47) | — | |
| SCHEMBL6208008 | 0.81 | MCL1 (0.47) | — | |
| SCHEMBL29921 | 0.81 | AGTR2 (0.56) | BDKRB2POLBAGTR2NPC1RAB9A | |
| SCHEMBL6515997 | 0.81 | AGTR2 (0.56) | BDKRB2POLBAGTR2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4462943-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1984-07-31 | — | — | US | disclosed |
| EP-0052991-A1 | Carboxyalkyl amino acid derivatives of various substituted prolines | E.R. Squibb & Sons, Inc. (US) | 1982-06-02 | — | — | EP | disclosed |
| US-4316906-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-02-23 | — | — | US | disclosed |