Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | TYMS | P04818 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7377905 | 0.80 | PDE3B (0.64) | MEN1KMT2AALDH1A1PDE3BPDE3A | |
| SCHEMBL7387266 | 0.77 | MEN1 (0.59) | MEN1KMT2AALDH1A1GAAPDE3B | |
| SCHEMBL10192086 | 0.75 | MEN1 (0.75) | MEN1KMT2AALDH1A1GAATP53 | |
| SCHEMBL7385190 | 0.74 | PDE3B (0.58) | MEN1KMT2APDE3BPDE3A | |
| SCHEMBL7383419 | 0.73 | PDE3B (0.70) | PDE3BPDE3A | |
| SCHEMBL7378034 | 0.72 | PDE3B (0.55) | ALDH1A1PDE3BPDE3ABRD4 | |
| SCHEMBL7377041 | 0.71 | PDE3B (0.76) | PDE3BPDE3A | |
| SCHEMBL808364 | 0.70 | ALDH1A1 (1.00) | MEN1KMT2AALDH1A1GAATP53 | |
| SCHEMBL7382397 | 0.70 | PDE3B (0.53) | PDE3BPDE3ABRD4 | |
| SCHEMBL2463204 | 0.70 | PDE3B (1.00) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4963561-A | Phosphodiesterase inhibitors | STERLING DRUG INC. (US) | 1990-10-16 | — | — | US | claimed |
| US-5010086-A | Enzyme inhibitor for treating congestive heart failure or hypertension in mammals | STERLING DRUG INC. (US) | 1991-04-23 | — | — | US | disclosed |
| US-4963561-A | Phosphodiesterase inhibitors | STERLING DRUG INC. (US) | 1990-10-16 | — | — | US | disclosed |