Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24260602 | 0.86 | POLB (0.44) | MAPTKMT2APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL7762330 | 0.84 | L3MBTL1 (0.53) | MAPTKMT2APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL24260273 | 0.83 | POLB (0.42) | MAPTKMT2APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL24260595 | 0.82 | L3MBTL1 (0.41) | MAPTKMT2APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL25919239 | 0.82 | MAPT (0.48) | MAPTKMT2APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL20910819 | 0.81 | ALDH1A1 (0.55) | MAPTKMT2APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL24260592 | 0.81 | POLB (0.40) | MAPTKMT2APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL28070422 | 0.81 | KMT2A (0.53) | MAPTKMT2AL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL24260264 | 0.81 | L3MBTL1 (0.50) | POLBL3MBTL1 | |
| SCHEMBL15826612 | 0.79 | L3MBTL1 (0.57) | MAPTKMT2APOLBL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376517-B1 | FOR TREATING VISION LOSS, PREVENTING VISION DEGENERATION, AND PROMOTING VISION REGENERATION (?NEOPSIS?) | GPI NIL HOLDINGS, INC. | 2002-04-23 | — | — | US | disclosed |
| US-6187784-B1 | ALOPECIA TREATMENT; FKBP-IMMUNOPHILIN AFFINITY | GPI NIL HOLDINGS, INC. | 2001-02-13 | — | — | US | disclosed |
| EP-1011650-A1 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | Amgen Inc., (US) | 2000-06-28 | — | — | EP | disclosed |
| WO-1999014998-A2 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | AMGEN INC. (US) | 1999-04-01 | — | — | WO | disclosed |