Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 7/20 | 0.60 |
| ▸ | THRB | P10828 | 7/20 | 0.60 |
| ▸ | CYP2J2 | P51589 | 2/20 | 0.56 |
| ▸ | HRH2 | P25021 | 7/20 | 0.53 |
| ▸ | HRH1 | P35367 | 7/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7383411 | 0.94 | CYP2J2 (0.55) | THRATHRBCYP2J2HRH2HRH1 | |
| SCHEMBL7391390 | 0.88 | CYP2J2 (0.54) | THRATHRBCYP2J2HRH2HRH1 | |
| SCHEMBL7394120 | 0.83 | DRD2 (0.53) | CYP2J2HRH2HRH1 | |
| SCHEMBL7389213 | 0.81 | NPC1 (0.54) | HRH2HRH1 | |
| SCHEMBL7395417 | 0.80 | DRD2 (0.60) | CYP2J2HRH2HRH1CYP3A4CYP2C9 | |
| SCHEMBL7381746 | 0.80 | TSHR (0.64) | HRH1 | |
| SCHEMBL7390664 | 0.80 | HTR1A (0.53) | HRH2HRH1 | |
| SCHEMBL7391420 | 0.80 | KMT2A (0.55) | CYP2J2HRH1CYP3A4 | |
| SCHEMBL7391863 | 0.80 | DRD2 (0.60) | CYP2J2HRH2HRH1CYP3A4CYP2C9 | |
| SCHEMBL7386508 | 0.80 | MAPT (0.61) | HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864039-A | THERAPEUTIC TREATMENT OF VARIOUS GASTROINTESTINAL DISEASES, CENTRAL NERVOUS DISORDERS, CARDIOVASCULAR DISORDERS, URINARY DISEASES, UROGENITAL DISORDERS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-01-26 | — | — | US | disclosed |
| EP-0873990-A1 | BENZOIC ACID COMPOUNDS AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-10-28 | — | — | EP | disclosed |