Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2J2 | P51589 | 1/20 | 0.54 |
| ▸ | HRH2 | P25021 | 8/20 | 0.50 |
| ▸ | HRH1 | P35367 | 8/20 | 0.50 |
| ▸ | THRA | P10827 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7383411 | 0.90 | CYP2J2 (0.55) | CYP2J2HRH2HRH1THRATHRB | |
| SCHEMBL7389512 | 0.88 | THRA (0.60) | CYP2J2HRH2HRH1THRATHRB | |
| SCHEMBL7394120 | 0.86 | DRD2 (0.53) | CYP2J2HRH2HRH1TSHRMEN1 | |
| SCHEMBL7387492 | 0.85 | DRD4 (0.47) | CYP2J2HRH2HRH1 | |
| SCHEMBL7389213 | 0.85 | NPC1 (0.54) | HRH2HRH1TSHRMEN1CHRM2 | |
| SCHEMBL7391863 | 0.83 | DRD2 (0.60) | CYP2J2HRH2HRH1TSHRMEN1 | |
| SCHEMBL7395417 | 0.83 | DRD2 (0.60) | CYP2J2HRH2HRH1TSHRMEN1 | |
| SCHEMBL7381746 | 0.83 | TSHR (0.64) | HRH1TSHRMEN1CHRM2HTR1A | |
| SCHEMBL7390664 | 0.83 | HTR1A (0.53) | HRH2HRH1TSHRMEN1CHRM2 | |
| SCHEMBL7391420 | 0.83 | KMT2A (0.55) | CYP2J2HRH1TSHRHTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864039-A | THERAPEUTIC TREATMENT OF VARIOUS GASTROINTESTINAL DISEASES, CENTRAL NERVOUS DISORDERS, CARDIOVASCULAR DISORDERS, URINARY DISEASES, UROGENITAL DISORDERS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-01-26 | — | — | US | disclosed |
| EP-0873990-A1 | BENZOIC ACID COMPOUNDS AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-10-28 | — | — | EP | disclosed |