Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PNMT | P11086 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6870416 | 0.90 | MEN1 (0.47) | IGF1RALOX15MEN1KMT2ANPC1 | |
| SCHEMBL6870419 | 0.90 | MEN1 (0.47) | IGF1RALOX15MEN1KMT2ANPC1 | |
| SCHEMBL5544409 | 0.73 | IGF1R (0.53) | IGF1RALOX15MEN1KMT2APNMT | |
| SCHEMBL15716656 | 0.73 | IGF1R (0.53) | IGF1RALOX15MEN1KMT2APNMT | |
| SCHEMBL14846527 | 0.71 | PNMT (0.50) | IGF1RALOX15MEN1KMT2APNMT | |
| SCHEMBL2114474 | 0.71 | ALDH1A1 (0.49) | ALOX15MEN1KMT2ANPC1CYP1A2 | |
| SCHEMBL9177318 | 0.70 | SIGMAR1 (0.62) | IGF1RALOX15MEN1KMT2APNMT | |
| SCHEMBL6079024 | 0.69 | SIGMAR1 (0.51) | IGF1RALOX15MEN1KMT2APNMT | |
| SCHEMBL1448394 | 0.69 | SIGMAR1 (0.63) | IGF1RALOX15MEN1KMT2APNMT | |
| SCHEMBL16771200 | 0.69 | PNMT (0.55) | IGF1RALOX15MEN1KMT2APNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0756596-B1 | TROPANE-2-ALDOXIME DERIVATIVES AS NEUROTRANSMITTER REUPTAKE INHIBITORS | NEUROSEARCH AS (DK) | 2002-08-21 | — | — | EP | disclosed |
| US-5736556-A | PARKINSON*S DISEASE; ANTIDEPRESSANTS; ANTIOBESITY; ANTINARCOLEPSY; DRUG ABRUSE | NEUROSEARCH A/S (DK) | 1998-04-07 | — | — | US | disclosed |
| EP-0756596-A1 | TROPANE-2-ALDOXIME DERIVATIVES AS NEUROTRANSMITTER REUPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 1997-02-05 | — | — | EP | disclosed |
| WO-1995028401-A1 | TROPANE-2-ALDOXINE DERIVATIVES AS NEUROTRANSMITTER REUPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 1995-10-26 | — | — | WO | disclosed |