Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | STK4 | Q13043 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17261188 | 0.87 | IP6K1 (0.37) | PGRL3MBTL1KMT2AIP6K1ALDH1A1 | |
| SCHEMBL17261184 | 0.87 | IP6K1 (0.37) | PGRL3MBTL1KMT2AIP6K1ALDH1A1 | |
| SCHEMBL1795281 | 0.79 | TRPV4 (0.43) | RXFP1PGRTRPV4L3MBTL1KMT2A | |
| SCHEMBL75146 | 0.79 | KMT2A (0.50) | RXFP1PGRTRPV4L3MBTL1KMT2A | |
| SCHEMBL4510489 | 0.79 | RXFP1 (0.42) | RXFP1PGRTRPV4L3MBTL1KMT2A | |
| SCHEMBL75334 | 0.77 | PGR (0.40) | RXFP1PGRTRPV4L3MBTL1KMT2A | |
| SCHEMBL1801337 | 0.75 | LMNA (0.38) | RXFP1PGRTRPV4L3MBTL1KMT2A | |
| SCHEMBL1801335 | 0.74 | RXFP1 (0.40) | RXFP1PGRTRPV4L3MBTL1KMT2A | |
| SCHEMBL2679245 | 0.70 | KMT2A (0.40) | PGRL3MBTL1KMT2ABACE1ALDH1A1 | |
| SCHEMBL1465378 | 0.69 | HSD17B10 (0.39) | PGRKMT2ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129389-B2 | Substituted oxindole derivatives, medicaments containing the latter and use thereof | ABBOTT GMBH & CO. KG (DE) | 2012-03-06 | — | — | US | disclosed |
| US-20090186904-A1 | Substituted Oxindole Derivatives, Medicaments Containing the Latter and Use Thereof | ABBOTT GMBH & CO. KG | 2009-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186904-A1 | Substituted Oxindole Derivatives, Medicaments Containing the Latter and Use Thereof | OXTR, AVPR2, AVPR1B | RXFP1 65/4885PGR 449/4885TRPV4 1033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.