Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11845387 | 0.88 | HDAC3 (0.65) | TDP1ATML3MBTL1NPC1RAB9A | |
| SCHEMBL1980273 | 0.87 | FOLH1 (0.61) | TDP1NPC1RAB9ACASP3SENP8 | |
| SCHEMBL11702735 | 0.86 | PPARG (0.54) | TDP1ATML3MBTL1CYP4F2CYP4A11 | |
| SCHEMBL4669025 | 0.85 | TDP1 (0.61) | TDP1ATML3MBTL1ALDH1A1PBRM1 | |
| SCHEMBL3112767 | 0.84 | KEAP1 (0.62) | TDP1ATML3MBTL1ALDH1A1PBRM1 | |
| SCHEMBL11301145 | 0.84 | TDP1 (0.59) | TDP1ATML3MBTL1ALDH1A1PBRM1 | |
| SCHEMBL7953016 | 0.84 | L3MBTL1 (0.59) | TDP1ATML3MBTL1ALDH1A1PBRM1 | |
| SCHEMBL10905589 | 0.84 | ATM (0.59) | TDP1ATML3MBTL1ALDH1A1PBRM1 | |
| SCHEMBL27691637 | 0.84 | L3MBTL1 (0.59) | TDP1ATML3MBTL1RAB9AALDH1A1 | |
| SCHEMBL16559877 | 0.82 | FOLH1 (0.66) | TDP1NPC1RAB9ACASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376517-B1 | FOR TREATING VISION LOSS, PREVENTING VISION DEGENERATION, AND PROMOTING VISION REGENERATION (?NEOPSIS?) | GPI NIL HOLDINGS, INC. | 2002-04-23 | — | — | US | claimed |
| EP-0777478-B1 | INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARM INC (US) | 2001-11-07 | — | — | EP | claimed |
| US-5843960-A | Inhibitors of rotamase enzyme activity | GPI NIL HOLDINGS, INC. (US) | 1998-12-01 | — | — | US | claimed |