Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | AOC1 | P19801 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ASPH | Q12797 | 1/20 | 0.38 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.38 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1242071 | 0.86 | CNR1 (0.50) | NPC1RAB9ACNR1CNR2POLB | |
| SCHEMBL6229052 | 0.77 | KMT2A (0.46) | NPC1RAB9APOLBMEN1KMT2A | |
| SCHEMBL1240858 | 0.77 | EPHX2 (0.46) | IDO1TDO2KDM4CAOC1AOC3 | |
| SCHEMBL8175174 | 0.76 | SMN1; SMN2 (0.56) | NPC1RAB9APOLBPKMMEN1 | |
| SCHEMBL12327196 | 0.76 | GLA (0.43) | NPC1RAB9APKMMEN1KMT2A | |
| SCHEMBL20376232 | 0.76 | LIPC (0.38) | CNR1CNR2KDM4CSOS1 | |
| SCHEMBL1241519 | 0.74 | NPC1 (0.45) | NPC1RAB9APOLBMEN1KMT2A | |
| SCHEMBL1241609 | 0.73 | AAK1 (0.46) | MEN1KMT2AIDO1TDO2KDM4C | |
| SCHEMBL1240818 | 0.73 | ASPH (0.37) | NPC1RAB9ACNR1CNR2MEN1 | |
| SCHEMBL22414312 | 0.73 | RAB9A (0.44) | NPC1RAB9APOLBKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138185-B2 | Urea glucokinase activators | NOVO NORDISK A/S (DK) | 2012-03-20 | — | — | US | disclosed |
| US-8138185-B2 | Urea glucokinase activators | NOVO NORDISK A/S (DK) | 2012-03-20 | — | — | US | disclosed |
| US-8138185-B2 | Urea glucokinase activators | NOVO NORDISK A/S (DK) | 2012-03-20 | — | — | US | disclosed |
| US-20100009989-A1 | Urea Glucokinase Activators | NOVO NORDISK A/S (DK) | 2010-01-14 | — | — | US | disclosed |
| US-20100009989-A1 | Urea Glucokinase Activators | NOVO NORDISK A/S (DK) | 2010-01-14 | — | — | US | disclosed |
| US-20100009989-A1 | Urea Glucokinase Activators | NOVO NORDISK A/S (DK) | 2010-01-14 | — | — | US | disclosed |
| EP-2118083-A1 | UREA GLUCOKINASE ACTIVATORS | Novo Nordisk A/S (DK) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008084043-A1 | UREA GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008084043-A1 | UREA GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009989-A1 | Urea Glucokinase Activators | GCK, GCKR, HK2 | NPC1 2846/4885RAB9A 3960/4885CNR1 4257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.