Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 9/20 | 0.49 |
| ▸ | DRD2 | P14416 | 9/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.45 |
| ▸ | HTR2A | P28223 | 4/20 | 0.45 |
| ▸ | HTR2B | P41595 | 4/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5957117 | 0.95 | HTR1A (0.52) | MAPTHTR1ADRD2SLC6A4HTR2A | |
| SCHEMBL5957061 | 0.85 | MAPT (0.49) | MAPTHTR1ADRD2SLC6A4HTR2A | |
| SCHEMBL7397493 | 0.83 | HTR1A (0.42) | MAPTHTR1ADRD2SLC6A4HTR2A | |
| SCHEMBL7397490 | 0.83 | HTR1A (0.42) | MAPTHTR1ADRD2SLC6A4HTR2A | |
| SCHEMBL5957113 | 0.81 | ALDH1A1 (0.59) | HTR1ADRD2SLC6A4HTR2AHTR2B | |
| SCHEMBL6319964 | 0.81 | MAPT (0.51) | MAPTHTR1ADRD2SLC6A4HTR2A | |
| SCHEMBL6767852 | 0.80 | HTR1A (0.51) | MAPTHTR1ADRD2HTR2AHTR2B | |
| SCHEMBL5957098 | 0.80 | DRD2 (0.48) | HTR1ADRD2SLC6A4HTR2AHTR2B | |
| SCHEMBL7828214 | 0.80 | MAPT (0.70) | MAPTHTR1A | |
| SCHEMBL5957134 | 0.79 | DRD2 (0.47) | HTR1ADRD2SLC6A4HTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1726592-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth a Corporation of the State of Delaware (US) | 2006-11-29 | — | — | EP | claimed |
| EP-1375503-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth (US) | 2004-01-02 | — | — | EP | claimed |
| EP-0771800-A2 | Dioxino derivatives and their use as dopamine agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | claimed |
| EP-1726592-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth a Corporation of the State of Delaware (US) | 2006-11-29 | — | — | EP | disclosed |
| EP-1375503-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth (US) | 2004-01-02 | — | — | EP | disclosed |
| US-5962465-A | BRAIN DISORDERS; PSYCHOLOGICAL DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-05 | — | — | US | disclosed |
| US-5756532-A | Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-05-26 | — | — | US | disclosed |