Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 13/20 | 0.69 |
| ▸ | CDK5 | Q00535 | 12/20 | 0.69 |
| ▸ | CDK5R1 | Q15078 | 12/20 | 0.69 |
| ▸ | CCNB2 | O95067 | 12/20 | 0.69 |
| ▸ | CDK1 | P06493 | 12/20 | 0.69 |
| ▸ | CCNB1 | P14635 | 12/20 | 0.69 |
| ▸ | CCNB3 | Q8WWL7 | 12/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.64 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.64 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | FLT4 | P35916 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5688422 | 0.81 | GSK3B (1.00) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL30319858 | 0.81 | GSK3B (1.00) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL6239759 | 0.78 | MAPT (1.00) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL4552964 | 0.76 | CDK1 (0.62) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL20920125 | 0.72 | GABRA1 (0.59) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL5263677 | 0.70 | MAPT (0.69) | GSK3BCDK5CCNB2CDK1CCNB1 | |
| SCHEMBL29855719 | 0.70 | MAPT (0.69) | GSK3BCDK5CCNB2CDK1CCNB1 | |
| SCHEMBL4162219 | 0.70 | MAPT (0.69) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL21828647 | 0.69 | CTSV (0.70) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL16301433 | 0.67 | HTR2A (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999065910-A9 | FUSED AZEPINONE CYCLIN DEPENDENT KINASE INHIBITORS | US HEALTH (US) | 2000-03-16 | — | — | WO | claimed |