Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.55 |
| ▸ | MMP2 | P08253 | 5/20 | 0.55 |
| ▸ | FPR2 | P25090 | 2/20 | 0.54 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.54 |
| ▸ | MMP12 | P39900 | 1/20 | 0.52 |
| ▸ | LIPE | Q05469 | 1/20 | 0.49 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7395651 | 0.87 | MMP13 (0.53) | MMP13MMP2FPR2PROKR1MMP12 | |
| SCHEMBL6096681 | 0.82 | FPR2 (0.61) | MMP13MMP2FPR2PROKR1MMP12 | |
| SCHEMBL6098249 | 0.80 | FPR2 (0.56) | MMP13MMP2FPR2PROKR1MMP12 | |
| SCHEMBL2092945 | 0.79 | LIPE (0.61) | MMP13MMP2FPR2PROKR1MMP12 | |
| SCHEMBL6096540 | 0.78 | MMP13 (0.57) | MMP13MMP2FPR2PROKR1MMP12 | |
| SCHEMBL6112364 | 0.76 | MMP13 (0.51) | MMP13MMP2FPR2PROKR1MMP12 | |
| SCHEMBL29716504 | 0.76 | SMN1; SMN2 (0.61) | MMP13MMP2FPR2PROKR1MMP12 | |
| SCHEMBL6098206 | 0.75 | MMP13 (0.60) | MMP13MMP2FPR2PROKR1MMP12 | |
| SCHEMBL23365220 | 0.75 | EPHX2 (0.62) | MMP13MMP2FPR2PROKR1LIPE | |
| SCHEMBL6097719 | 0.74 | MMP13 (0.52) | MMP13MMP2FPR2PROKR1MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157021-A1 | SULFAMATO HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000046221-A1 | SULFAMATO HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-08-10 | — | — | WO | disclosed |