Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 12/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.36 |
| ▸ | CLK2 | P49760 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 2/20 | 0.34 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739855 | 1.00 | PIK3CD (0.37) | PIK3CDROCK2RPS6KB1CLK2CLK4 | |
| SCHEMBL740638 | 0.89 | GSK3B (0.37) | ROCK2ROCK1BTK | |
| SCHEMBL740637 | 0.89 | GSK3B (0.37) | ROCK2ROCK1BTK | |
| SCHEMBL741966 | 0.87 | AKT1 (0.36) | BTK | |
| SCHEMBL742052 | 0.87 | AKT1 (0.36) | BTK | |
| SCHEMBL740397 | 0.87 | ALDH1A1 (0.36) | FASNCTSCBTK | |
| SCHEMBL740398 | 0.87 | ALDH1A1 (0.36) | FASNCTSCBTK | |
| SCHEMBL2788959 | 0.86 | PROKR1 (0.37) | PIK3CDROCK2RPS6KB1CLK2CLK4 | |
| SCHEMBL742029 | 0.86 | NSD2 (0.36) | CTSC | |
| SCHEMBL742030 | 0.86 | NSD2 (0.36) | CTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |