Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTR3B | O95264 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7405167 | 0.79 | IRAK4 (0.42) | PTGS1ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL537351 | 0.78 | PDPK1 (0.50) | RAB9APTGS1PDPK1ALDH1A1CYP1A2 | |
| SCHEMBL537395 | 0.75 | PTGS1 (0.65) | PTGS1PDPK1ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL537523 | 0.75 | TGFBR1 (0.44) | RAB9APTGS1ALDH1A1KDM4EMAPK1 | |
| SCHEMBL7330567 | 0.73 | PTGS1 (0.63) | PTGS1PDPK1ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL537761 | 0.72 | MAPK1 (0.50) | NPC1RAB9APTGS1ALDH1A1MAPK1 | |
| SCHEMBL31199040 | 0.71 | CRACR2A (0.42) | CNR2 | |
| SCHEMBL31199062 | 0.71 | MAPT (0.44) | CNR2NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL7407050 | 0.71 | PTGS1 (0.39) | RAB9APTGS1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7405141 | 0.70 | PTGS1 (0.44) | CNR2PTGS1PDPK1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750550-A | RESPIRATORY SYSTEM DISORDERS | SANOFI (FR) | 1998-05-12 | — | — | US | disclosed |
| WO-1997010243-A1 | 2-(PYRAZOL-5-YL-OXYMETHYL)-1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI (US) | 1997-03-20 | — | — | WO | disclosed |