Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL537523 | 0.79 | TGFBR1 (0.44) | PTGS1MAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL7399245 | 0.79 | CNR2 (0.42) | PTGS1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL537395 | 0.76 | PTGS1 (0.65) | PTGS1KLKB1MAPTKDM4EMEN1 | |
| SCHEMBL7330567 | 0.75 | PTGS1 (0.63) | PTGS1KLKB1MAPTKDM4EMEN1 | |
| SCHEMBL12075255 | 0.75 | KDM4E (0.51) | PTGS1KLKB1MAPTKDM4EMEN1 | |
| SCHEMBL2261447 | 0.74 | PTGS1 (0.41) | PTGS1KLKB1 | |
| SCHEMBL538151 | 0.73 | PTGS2 (0.51) | PTGS1 | |
| SCHEMBL7406011 | 0.73 | PTGS1 (0.49) | PTGS1MAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL537351 | 0.73 | PDPK1 (0.50) | PTGS1ALDH1A1 | |
| SCHEMBL31522202 | 0.73 | TRPV1 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750550-A | RESPIRATORY SYSTEM DISORDERS | SANOFI (FR) | 1998-05-12 | — | — | US | disclosed |
| WO-1997010243-A1 | 2-(PYRAZOL-5-YL-OXYMETHYL)-1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI (US) | 1997-03-20 | — | — | WO | disclosed |