Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401016 | 0.81 | DRD2 (0.66) | MAOAMAP2K1DRD2BRD4 | |
| SCHEMBL7403885 | 0.81 | LSS (0.47) | DRD2HTR2AHTR2CL3MBTL1 | |
| SCHEMBL7402278 | 0.81 | DRD2 (0.50) | MAOAMAP2K1DRD2KMT2AALDH1A1 | |
| SCHEMBL7398714 | 0.81 | MAOA (0.48) | MAOAMAP2K1DRD2KMT2AALDH1A1 | |
| SCHEMBL7402707 | 0.80 | BRD4 (0.54) | BRD4 | |
| SCHEMBL7398210 | 0.80 | KDM4E (0.47) | MAOAMAP2K1KMT2AALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL7398529 | 0.79 | LSS (0.46) | DRD2HTR2AHTR2CL3MBTL1 | |
| SCHEMBL9359327 | 0.78 | MAOA (0.58) | MAOAMAP2K1DRD2KMT2AALDH1A1 | |
| SCHEMBL6610340 | 0.77 | MAOA (0.57) | MAOAMAP2K1KMT2AALDH1A1PTGS1 | |
| SCHEMBL4403006 | 0.76 | DRD2 (0.68) | DRD2ALDH1A1GAAHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5206233-A | Antidepressants, antiischemic agents | WARNER-LAMBERT COMPANY (US) | 1993-04-27 | — | — | US | claimed |
| WO-1993004053-A1 | SUBSTITUTED THIAZEPINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-04 | — | — | WO | claimed |
| US-5206233-A | Antidepressants, antiischemic agents | WARNER-LAMBERT COMPANY (US) | 1993-04-27 | — | — | US | disclosed |
| WO-1993004053-A1 | SUBSTITUTED THIAZEPINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-04 | — | — | WO | disclosed |