Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.66 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7402278 | 0.89 | DRD2 (0.50) | DRD2MAOAMAP2K1BRD4HRH3 | |
| SCHEMBL7399918 | 0.85 | DRD2 (0.63) | DRD2SLC6A4BRD4 | |
| SCHEMBL7399263 | 0.81 | MAOA (0.51) | DRD2MAOAMAP2K1BRD4 | |
| SCHEMBL466984 | 0.79 | SIGMAR1 (0.53) | DRD2HRH3 | |
| SCHEMBL14266745 | 0.79 | MAOA (0.49) | DRD2MAOASLC6A4MAP2K1HRH3 | |
| SCHEMBL7397293 | 0.75 | BRD4 (0.56) | MAOAMAP2K1BRD4 | |
| SCHEMBL25564212 | 0.75 | DRD2 (0.89) | DRD2SLC6A4KDM2B | |
| SCHEMBL7398714 | 0.75 | MAOA (0.48) | DRD2MAOASLC6A4MAP2K1BRD4 | |
| SCHEMBL7402174 | 0.74 | DRD2 (0.49) | DRD2BRD4 | |
| SCHEMBL7398210 | 0.74 | KDM4E (0.47) | MAOAMAP2K1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5206233-A | Antidepressants, antiischemic agents | WARNER-LAMBERT COMPANY (US) | 1993-04-27 | — | — | US | claimed |
| WO-1993004053-A1 | SUBSTITUTED THIAZEPINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-04 | — | — | WO | claimed |
| US-5206233-A | Antidepressants, antiischemic agents | WARNER-LAMBERT COMPANY (US) | 1993-04-27 | — | — | US | disclosed |
| WO-1993004053-A1 | SUBSTITUTED THIAZEPINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-04 | — | — | WO | disclosed |