Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 known ✓ | Q13639 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7398676 | 0.96 | KDM1A (0.40) | KDM1AHCRTR1HCRTR2ACKR3OPRM1 | |
| SCHEMBL7398566 | 0.88 | HCRTR1 (0.35) | HCRTR1HCRTR2ACKR3OPRM1KMT2A | |
| Fumaric Acid SCHEMBL7399492 | 0.87 | HCRTR1 (0.33) | HCRTR1HCRTR2ACKR3HTR4KMT2A | |
| Maleic Acid SCHEMBL7399489 | 0.87 | HCRTR1 (0.33) | HCRTR1HCRTR2ACKR3HTR4KMT2A | |
| Maleic Acid SCHEMBL8006649 | 0.87 | KDM1A (0.38) | KDM1AHCRTR1HCRTR2ACKR3KMT2A | |
| Maleic Acid SCHEMBL7398825 | 0.86 | SMN1; SMN2 (0.35) | HCRTR1HCRTR2ACKR3HTR4KMT2A | |
| Fumaric Acid SCHEMBL7398829 | 0.86 | SMN1; SMN2 (0.35) | HCRTR1HCRTR2ACKR3HTR4KMT2A | |
| Fumaric Acid SCHEMBL7400191 | 0.86 | ACKR3 (0.40) | HCRTR1HCRTR2ACKR3KMT2A | |
| Maleic Acid SCHEMBL7400186 | 0.86 | ACKR3 (0.40) | HCRTR1HCRTR2ACKR3KMT2A | |
| SCHEMBL1039396 | 0.83 | HTR4 (0.40) | KDM1AHCRTR1HCRTR2ACKR3HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618827-A | TREATING GASTROINTESTINAL, URINARY, CARDIOVASCULAR, CENTRAL NERVOUS SYTEM DISORDERS | GLAXO GROUP LIMITED (GB) | 1997-04-08 | — | — | US | disclosed |
| EP-0640081-A1 | SUBSTITUTED PHENYLCARBAMATES AND PHENYLUREAS, THEIR PREPARATION AND THEIR USE AS 5-HT ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993020071-A1 | SUBSTITUTED PHENYLCARBAMATES AND PHENYLUREAS, THEIR PREPARATION AND THEIR USE AS 5-HT ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1993-10-14 | — | — | WO | disclosed |