Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.32 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.32 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.31 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.31 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.31 |
| ▸ | HTR4 known ✓ | Q13639 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7399489 | 1.00 | HCRTR1 (0.33) | HCRTR1HCRTR2ACKR3KMT2AKCNH2 | |
| SCHEMBL7398680 | 0.96 | HCRTR1 (0.35) | HCRTR1HCRTR2ACKR3KMT2AKCNH2 | |
| Fumaric Acid SCHEMBL7398829 | 0.89 | SMN1; SMN2 (0.35) | HCRTR1HCRTR2ACKR3KMT2AKCNH2 | |
| Maleic Acid SCHEMBL7398825 | 0.89 | SMN1; SMN2 (0.35) | HCRTR1HCRTR2ACKR3KMT2AKCNH2 | |
| SCHEMBL1039396 | 0.87 | HTR4 (0.40) | HCRTR1HCRTR2ACKR3KMT2AKCNH2 | |
| Maleic Acid SCHEMBL7399487 | 0.87 | KDM1A (0.38) | HCRTR1HCRTR2ACKR3KMT2AHTR4 | |
| SCHEMBL8836846 | 0.86 | HCRTR1 (0.35) | HCRTR1HCRTR2ACKR3KMT2AKCNH2 | |
| Fumaric Acid SCHEMBL7400191 | 0.85 | ACKR3 (0.40) | HCRTR1HCRTR2ACKR3KMT2ACARM1 | |
| Maleic Acid SCHEMBL7400186 | 0.85 | ACKR3 (0.40) | HCRTR1HCRTR2ACKR3KMT2ACARM1 | |
| SCHEMBL7399420 | 0.84 | HTT (0.37) | HCRTR1HCRTR2ACKR3KMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618827-A | TREATING GASTROINTESTINAL, URINARY, CARDIOVASCULAR, CENTRAL NERVOUS SYTEM DISORDERS | GLAXO GROUP LIMITED (GB) | 1997-04-08 | — | — | US | disclosed |
| EP-0640081-A1 | SUBSTITUTED PHENYLCARBAMATES AND PHENYLUREAS, THEIR PREPARATION AND THEIR USE AS 5-HT ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993020071-A1 | SUBSTITUTED PHENYLCARBAMATES AND PHENYLUREAS, THEIR PREPARATION AND THEIR USE AS 5-HT ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1993-10-14 | — | — | WO | disclosed |