⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17060528 | 0.78 | TSHR (0.31) | — | |
| SCHEMBL11684533 | 0.76 | ESR1 (0.32) | — | |
| SCHEMBL138020 | 0.74 | TSHR (0.52) | — | |
| SCHEMBL7302373 | 0.73 | TAAR1 (0.33) | — | |
| SCHEMBL11618214 | 0.73 | TSHR (0.31) | — | |
| SCHEMBL533142 | 0.73 | — | — | |
| SCHEMBL3167744 | 0.72 | TSHR (0.50) | — | |
| SCHEMBL27294325 | 0.72 | BDKRB2 (0.32) | — | |
| SCHEMBL27524215 | 0.70 | TSHR (0.48) | — | |
| SCHEMBL2063450 | 0.70 | CHRNA7 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638075-B1 | THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS | OTSUKA PHARMA CO LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| US-6197774-B1 | THERAPY FOR ASTHMA, SKIN DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-06 | — | — | US | disclosed |
| EP-1019501-A1 | NOVEL PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998041526-A1 | NOVEL PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-24 | — | — | WO | disclosed |
| US-5677322-A | THERAPY FOR AGING, DIABETES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-10-14 | — | — | US | disclosed |
| EP-0474955-B1 | Process for the preparation of N-phosphonomethylglycine by means of an oxidation/dealkylation process | MONSANTO CO (US) | 1995-07-19 | — | — | EP | disclosed |
| EP-0282895-B1 | 2-oxa-isocephem compounds, compositions containing same and processes for preparing same | OTSUKA PHARMA CO LTD (JP) | 1995-06-07 | — | — | EP | disclosed |
| EP-0638075-A1 | THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-15 | — | — | EP | disclosed |
| WO-1994019335-A1 | THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-01 | — | — | WO | disclosed |
| EP-0297369-B1 | Process for the preparation of N-phosphonomethylglycine | HOECHST AG (DE) | 1994-03-02 | — | — | EP | disclosed |
| US-4407764-A | HERBICIDES | MONSANTO COMPANY (US) | 1983-10-04 | — | — | US | disclosed |
| US-4407763-A | Thiosulfenamide derivatives of N-phosphonomethylglycinonitriles | MONSANTO COMPANY (US) | 1983-10-04 | — | — | US | disclosed |
| US-4405356-A | Ester derivatives of N-arylsulfinyl-N-phosphonomethylglycinates as herbicides | MONSANTO COMPANY (US) | 1983-09-20 | — | — | US | disclosed |
| US-4401604-A | Process for preparing thiosulfenamide derivatives of N-phosphonomethylglycine triesters | MONSANTO COMPANY (US) | 1983-08-30 | — | — | US | disclosed |
| US-4401455-A | REACTING AN N-DIARYLPHOSPHONOMETHYL GLYCINE ESTER WITH AN ALKYL SULFENYL CHLORIDE; POSTEMERGENCE HERBICIDES | MONSANTO COMPANY (US) | 1983-08-30 | — | — | US | disclosed |
| US-4395374-A | HERBICIDES, PLANT GROWTH REGULATORS | MONSANTO COMPANY (US) | 1983-07-26 | — | — | US | disclosed |
| US-4395276-A | Thiosulfenamide derivatives of N-phosphonomethylglycinonitriles as herbicides | MONSANTO COMPANY (US) | 1983-07-26 | — | — | US | disclosed |
| EP-0055925-A2 | Alkyl N-arylsulfenyl-N-diaryloxy-phosphinylmethylglycinates and their use as herbicides | MONSANTO COMPANY (US) | 1982-07-14 | — | — | EP | disclosed |
| US-4300943-A | Ester derivatives of N-arylthio-N-phosphonomethylglycinonitrile | MONSANTO COMPANY (US) | 1981-11-17 | — | — | US | disclosed |
| US-4252554-A | Herbicidal ester derivatives of N-arylthio-N-phosphonomethylglycinonitrile | MONSANTO COMPANY (US) | 1981-02-24 | — | — | US | disclosed |