Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | UGCG | Q16739 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GFER | P55789 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7403392 | 0.94 | MAPK1 (0.56) | MAPK1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL7404596 | 0.83 | DRD2 (0.59) | MAPK1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL7397389 | 0.80 | DRD4 (0.66) | — | |
| SCHEMBL9014716 | 0.79 | HTR1A (0.47) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL7402337 | 0.79 | DRD2 (0.48) | MEN1KMT2AUGCGMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL7399648 | 0.79 | DRD4 (0.64) | — | |
| SCHEMBL7402692 | 0.78 | MAPK1 (0.55) | MAPK1MEN1KMT2AMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL7398492 | 0.78 | DRD2 (0.48) | MAPK1MEN1KMT2AUGCGMAPT | |
| SCHEMBL8347285 | 0.76 | MTNR1B (0.61) | MAPK1MAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL27529224 | 0.76 | MTNR1B (0.61) | MAPK1MAPTALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6133446-A | Heterocyclic compounds for the treatment of CNS and cardiovascular disorders | PHARMACIA & UPJOHN COMPANY (US) | 2000-10-17 | — | — | US | disclosed |
| WO-1995018118-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS | THE UPJOHN COMPANY (US) | 1995-07-06 | — | — | WO | disclosed |