SCHEMBL740056

SCHEMBL740056

CSc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)NCC(F)(F)F

nearest known ligand 0.34

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ULK1 O75385 1/20 0.34
PTGES O14684 1/20 0.34
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
GABRA5 P31644 3/20 0.32
F2 P00734 2/20 0.31
F10 P00742 2/20 0.31
PRSS1 P07477 1/20 0.31
MAPT P10636 1/20 0.31
SLC6A9 P48067 1/20 0.31
LMNA P02545 1/20 0.30
ORAI1 Q96D31 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL119374 0.89 PTGES (0.35) ULK1PTGESCA1CA2GABRA5
SCHEMBL12846412 0.88 PTGES (0.34) ULK1PTGESCA1CA2GABRA5
SCHEMBL738501 0.87 PTGES (0.36) ULK1PTGESCA1CA2GABRA5
SCHEMBL30631643 0.87 F10 (0.34) ULK1PTGESCA1CA2GABRA5
SCHEMBL30631646 0.87 F10 (0.34) ULK1PTGESCA1CA2GABRA5
SCHEMBL739005 0.87 F10 (0.34) ULK1PTGESCA1CA2GABRA5
SCHEMBL738531 0.86 HPGD (0.44) MAPTLMNA
SCHEMBL738326 0.86 ROCK2 (0.36) PTGESMAPTLMNA
SCHEMBL30631649 0.86 ROCK2 (0.36) PTGESMAPTLMNA
SCHEMBL738467 0.86 PTGES (0.34) ULK1PTGESCA1CA2GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230355590-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL CORPORATION (JP) 2023-11-09 US disclosed
US-10874645-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL CORPORATION (JP) 2020-12-29 US disclosed
US-20200155511-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL CORPORATION (JP) 2020-05-21 US disclosed
US-10596157-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL CORPORATION (JP) 2020-03-24 US disclosed
US-20180318266-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2018-11-08 US disclosed
US-20170065565-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2017-03-09 US disclosed
EP-1731512-B9 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND NOXIOUS ORGANISM CONTROL AGENT NISSAN CHEMICAL IND LTD (JP) 2017-03-01 EP disclosed
US-20150105398-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL CORPORATION (JP) 2015-04-16 US disclosed
US-8946492-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2015-02-03 US disclosed
EP-1731512-B1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND NOXIOUS ORGANISM CONTROL AGENT NISSAN CHEMICAL IND LTD (JP) 2014-10-01 EP disclosed
US-20130296559-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL CORPORATION (JP) 2013-11-07 US disclosed
US-8492311-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2013-07-23 US disclosed
US-20120172615-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2012-07-05 US disclosed
US-8138213-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2012-03-20 US disclosed
US-20110251398-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-10-13 US disclosed
US-8022089-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-09-20 US disclosed
US-7662972-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2010-02-16 US disclosed
US-20090312330-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2009-12-17 US disclosed
US-20070066617-A1 Insecticidal and acaricidal activity for many agricultural insect pests, spider mites; endo- or ecto-parasiticide for mammals or birds; veterinary medicine; environmentally friendly NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2007-03-22 US disclosed
EP-1731512-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND NOXIOUS ORGANISM CONTROL AGENT Nissan Chemical Industries, Ltd. (JP) 2006-12-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150105398-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE C3AR1, C5, C9 ULK1 4822/4885PTGES 4585/4885CA1 811/4885
US-20230355590-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE HDAC7, ACHE, BRDT ULK1 4300/4885PTGES 3698/4885CA1 1596/4885
US-10596157-B2 Isoxazoline-substituted benzamide compound and pesticide CHRM3, C3AR1, C9 ULK1 4847/4885PTGES 4543/4885CA1 702/4885
US-20120172615-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE C3AR1, C5, C9 ULK1 4802/4885PTGES 4436/4885CA1 991/4885
US-20180318266-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE CHRM3, C3AR1, C9 ULK1 4847/4885PTGES 4543/4885CA1 702/4885
US-20090312330-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE ATM, CHRM1, NAT1 ULK1 4476/4885PTGES 4055/4885CA1 1945/4885
US-10874645-B2 Isoxazoline-substituted benzamide compound and pesticide C3AR1, C5, C9 ULK1 4822/4885PTGES 4489/4885CA1 916/4885
US-20130296559-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE C5, C3AR1, C9 ULK1 4824/4885PTGES 4488/4885CA1 955/4885
US-20110251398-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE CBR3, CHRM1, CBR1 ULK1 4809/4885PTGES 4648/4885CA1 475/4885
US-20170065565-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE C3AR1, C5, C9 ULK1 4823/4885PTGES 4562/4885CA1 883/4885
US-20070066617-A1 Insecticidal and acaricidal activity for many agricultural insect pests, spider mites; endo- or ecto-parasiticide for mammals or birds; veterinary medicine; environmentally friendly CHRM1, DDT, ATM ULK1 2728/4885PTGES 3525/4885CA1 2192/4885
US-20200155511-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE C3AR1, C5, C9 ULK1 4822/4885PTGES 4489/4885CA1 916/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.