Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 1.00 |
| ▸ | PDE4A | P27815 | 18/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 18/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 18/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 18/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7400585 | 0.88 | PDE4A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7451032 | 0.76 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400136 | 0.73 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9258758 | 0.73 | PDE4A (0.74) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7451337 | 0.71 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9258768 | 0.71 | PDE4A (0.72) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400872 | 0.71 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL978793 | 0.71 | ALDH1A1 (0.61) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400643 | 0.69 | PDE5A (0.55) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13986123 | 0.69 | PDE5A (0.75) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563168-B1 | XANTHINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 2000-07-05 | — | — | EP | claimed |
| EP-0563168-B1 | XANTHINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 2000-07-05 | — | — | EP | disclosed |
| US-5409934-A | Antiallergens | BEECHAM GROUP P.L.C. (GB) | 1995-04-25 | — | — | US | disclosed |
| EP-0563168-A1 | XANTHINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1993-10-06 | — | — | EP | disclosed |
| WO-1992011260-A1 | XANTHINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1992-07-09 | — | — | WO | disclosed |