SCHEMBL7400876

SCHEMBL7400876

COc1ccc2c(N)c(C(=O)O)sc2c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.58
HTT P42858 2/20 0.58
NPSR1 Q6W5P4 2/20 0.58
RXFP1 Q9HBX9 2/20 0.58
PRNP P04156 1/20 0.58
TSHR P16473 1/20 0.58
PPARG P37231 1/20 0.58
MAPK10 P53779 1/20 0.58
NCOA2 Q15596 1/20 0.58
ALDH1A1 P00352 7/20 0.55
KDM4E B2RXH2 6/20 0.55
MAPT P10636 5/20 0.55
GAA P10253 4/20 0.55
LMNA P02545 1/20 0.55
CES2 O00748 1/20 0.48
HPGD P15428 4/20 0.48
HSD17B10 Q99714 4/20 0.48
GLA P06280 3/20 0.48
ALOX15 P16050 3/20 0.48
MEN1 O00255 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8435973 0.86 KDM4E (0.66) MAPK1HTTNPSR1RXFP1PRNP
SCHEMBL2896302 0.83 CES2 (0.63) MAPK1HTTNPSR1RXFP1PRNP
SCHEMBL5453267 0.81 RXFP1 (0.76) MAPK1HTTNPSR1RXFP1PRNP
SCHEMBL3493247 0.79 L3MBTL1 (0.56) MAPK1HTTNPSR1RXFP1PRNP
SCHEMBL19478163 0.79 BCKDK (0.46) MAPK1HTTRXFP1ALDH1A1KDM4E
SCHEMBL11684474 0.78 MCL1 (0.71) NPSR1RXFP1ALDH1A1KDM4EMAPT
SCHEMBL2960466 0.78 BCKDK (0.67) RXFP1TSHRALDH1A1KDM4EMAPT
SCHEMBL9374983 0.77 EDNRA (0.50) MAPK1HTTNPSR1RXFP1PRNP
SCHEMBL9373001 0.77 ICAM1 (0.62) MAPK1HTTNPSR1RXFP1PRNP
SCHEMBL5306006 0.75 PRNP (0.51) MAPK1HTTNPSR1RXFP1PRNP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0891358-A1 OXAZOLIDIN-2-ONE DERIVATIVES, PREPARATION METHOD THEREFOR AND THERAPEUTICAL USE THEREOF SYNTHELABO (FR) 1999-01-20 EP disclosed
WO-1997013768-A1 OXAZOLIDIN-2-ONE DERIVATIVES, PREPARATION METHOD THEREFOR AND THERAPEUTICAL USE THEREOF SYNTHELABO (FR) 1997-04-17 WO disclosed