Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7396649 | 0.99 | HDAC6 (0.53) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7401338 | 0.99 | HDAC6 (0.53) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7398844 | 0.99 | HDAC6 (0.53) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7401263 | 0.82 | SIGMAR1 (0.56) | KDM4EALDH1A1KMT2ASIGMAR1 | |
| SCHEMBL7399289 | 0.82 | SIGMAR1 (0.56) | KDM4EALDH1A1KMT2ASIGMAR1 | |
| SCHEMBL7447647 | 0.82 | SIGMAR1 (0.56) | KDM4EALDH1A1KMT2ASIGMAR1 | |
| SCHEMBL8904149 | 0.82 | HDAC6 (0.55) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8905029 | 0.82 | HDAC6 (0.55) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9051255 | 0.81 | SLC18A3 (0.58) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7404627 | 0.81 | HTR7 (0.55) | FAAHKDM4EALDH1A1POLBKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995024390-A1 | NOVEL PHENYL(-ALKYL/ALKOXY)-1-AMINOALKYL-SUBSTITUTED PIPERIDINES AND PYRROLIDINES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-09-14 | — | — | WO | disclosed |