SCHEMBL7401217

SCHEMBL7401217

NC(=O)c1ccc(N2CCN(CCC3CCCc4ccccc43)CC2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.51
PARP2 Q9UGN5 1/20 0.51
SIGMAR1 Q99720 4/20 0.50
DRD2 P14416 3/20 0.49
ALDH1A1 P00352 1/20 0.49
LMNA P02545 1/20 0.49
MAPT P10636 1/20 0.49
HTR1D P28221 1/20 0.48
DRD4 P21917 2/20 0.48
CA12 O43570 1/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
CA4 P22748 1/20 0.48
CA6 P23280 1/20 0.48
CA5A P35218 1/20 0.48
CA7 P43166 1/20 0.48
CA9 Q16790 1/20 0.48
CA13 Q8N1Q1 1/20 0.48
CA14 Q9ULX7 1/20 0.48
CA5B Q9Y2D0 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7395941 0.99 PARP1 (0.50) PARP1PARP2SIGMAR1DRD2ALDH1A1
SCHEMBL7403486 0.94 DRD2 (0.50) DRD2HTR1DDRD4CA12CA1
SCHEMBL7403278 0.85 ALDH1A1 (0.59) SIGMAR1DRD2ALDH1A1LMNAMAPT
Hydrochloric Acid SCHEMBL7401194 0.84 ALDH1A1 (0.58) SIGMAR1DRD2ALDH1A1LMNAMAPT
SCHEMBL7401930 0.83 DRD2 (0.67) SIGMAR1DRD2ALDH1A1LMNAMAPT
Hydrochloric Acid SCHEMBL8178534 0.82 DRD2 (0.66) SIGMAR1DRD2ALDH1A1LMNAMAPT
SCHEMBL5698979 0.81 DRD2 (0.73) SIGMAR1DRD2HTR1DDRD4CA12
SCHEMBL7397389 0.81 DRD4 (0.66) SIGMAR1DRD2HTR1DDRD4
SCHEMBL7404378 0.80 MAPT (0.52) SIGMAR1DRD2MAPTHTR1DDRD4
Hydrochloric Acid SCHEMBL8178893 0.80 DRD2 (0.72) SIGMAR1DRD2HTR1DDRD4CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0737189-A1 HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS PHARMACIA & UPJOHN COMPANY (US) 1996-10-16 EP claimed
WO-1995018118-A1 HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS THE UPJOHN COMPANY (US) 1995-07-06 WO claimed
US-6133446-A Heterocyclic compounds for the treatment of CNS and cardiovascular disorders PHARMACIA & UPJOHN COMPANY (US) 2000-10-17 US disclosed
EP-0737189-A1 HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS PHARMACIA & UPJOHN COMPANY (US) 1996-10-16 EP disclosed
WO-1995018118-A1 HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS THE UPJOHN COMPANY (US) 1995-07-06 WO disclosed