SCHEMBL7401930

SCHEMBL7401930

NS(=O)(=O)c1ccc(N2CCN(CCC3CCCc4ccccc43)CC2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 4/20 0.67
DRD4 P21917 3/20 0.67
CA12 O43570 1/20 0.67
CA1 P00915 1/20 0.67
CA2 P00918 1/20 0.67
CA4 P22748 1/20 0.67
CA6 P23280 1/20 0.67
CA5A P35218 1/20 0.67
CA7 P43166 1/20 0.67
CA9 Q16790 1/20 0.67
CA13 Q8N1Q1 1/20 0.67
CA14 Q9ULX7 1/20 0.67
CA5B Q9Y2D0 1/20 0.67
SIGMAR1 Q99720 4/20 0.50
HTR1A P08908 1/20 0.45
ADRA2A P08913 1/20 0.45
ADRA2B P18089 1/20 0.45
ADRA2C P18825 1/20 0.45
DRD1 P21728 1/20 0.45
ADRA1D P25100 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8178534 0.99 DRD2 (0.66) DRD2DRD4CA12CA1CA2
SCHEMBL27524409 0.94 DRD2 (0.69) DRD2DRD4CA12CA1CA2
SCHEMBL7403278 0.83 ALDH1A1 (0.59) DRD2DRD4SIGMAR1HTR1AADRA2A
SCHEMBL7401217 0.83 PARP1 (0.51) DRD2DRD4CA12CA1CA2
Hydrochloric Acid SCHEMBL7401194 0.82 ALDH1A1 (0.58) DRD2DRD4SIGMAR1HTR1AADRA2A
SCHEMBL10407542 0.82 CA2 (0.63) DRD2DRD4CA12CA1CA2
Hydrochloric Acid SCHEMBL7395941 0.82 PARP1 (0.50) DRD2DRD4CA12CA1CA2
SCHEMBL7406795 0.81 SIGMAR1 (0.47) DRD2DRD4SIGMAR1HTR1AHTR2A
SCHEMBL7397389 0.81 DRD4 (0.66) DRD2DRD4SIGMAR1HTR1AHTR2A
Hydrochloric Acid SCHEMBL7401132 0.80 SIGMAR1 (0.47) DRD2DRD4SIGMAR1HTR1AHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0737189-A1 HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS PHARMACIA & UPJOHN COMPANY (US) 1996-10-16 EP claimed
WO-1995018118-A1 HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS THE UPJOHN COMPANY (US) 1995-07-06 WO claimed
US-6133446-A Heterocyclic compounds for the treatment of CNS and cardiovascular disorders PHARMACIA & UPJOHN COMPANY (US) 2000-10-17 US disclosed
EP-0737189-A1 HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS PHARMACIA & UPJOHN COMPANY (US) 1996-10-16 EP disclosed
WO-1995018118-A1 HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS THE UPJOHN COMPANY (US) 1995-07-06 WO disclosed