Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | EDNRB | P24530 | 4/20 | 0.55 |
| ▸ | EDNRA | P25101 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7404248 | 0.89 | EDNRB (0.61) | ALDH1A1RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL7397215 | 0.88 | ALDH1A1 (0.52) | ALDH1A1RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL25203201 | 0.83 | RAB9A (0.70) | ALDH1A1RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL7401629 | 0.81 | HPGD (0.51) | ALDH1A1RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL14518414 | 0.80 | ALDH1A1 (0.70) | ALDH1A1RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL8736580 | 0.77 | ALDH1A1 (0.68) | ALDH1A1RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL7399206 | 0.76 | ALDH1A1 (0.66) | ALDH1A1RAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL27981072 | 0.75 | RAB9A (0.87) | ALDH1A1RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL389405 | 0.75 | SMN1; SMN2 (0.66) | ALDH1A1RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL26624014 | 0.75 | KMT2A (0.72) | ALDH1A1RAB9ANPC1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650484-B1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2000-01-26 | — | — | EP | disclosed |
| US-5559105-A | ANTAGONIST FOR ENDOTHELIN RECEPTORS, HYPOTENSIVE AGENTS, TREATMENT OF KIDNEY FAILURE OR CEREBROVASCULAR DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-09-24 | — | — | US | disclosed |
| EP-0650484-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-05-03 | — | — | EP | disclosed |
| WO-1994002474-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-02-03 | — | — | WO | disclosed |