Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7399671 | 0.88 | ADAM17 (0.51) | ADAM17LMNAKDM4ENPC1ALDH1A1 | |
| SCHEMBL6595607 | 0.83 | ADAM17 (0.72) | ADAM17MMP2 | |
| SCHEMBL7401359 | 0.82 | ADAM17 (0.61) | ADAM17MMP2MMP9 | |
| SCHEMBL7535614 | 0.76 | MMP2 (0.64) | ADAM17MMP2MMP9 | |
| SCHEMBL6629887 | 0.75 | SMN1; SMN2 (0.49) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL6594904 | 0.74 | ADAM17 (0.60) | ADAM17MMP2 | |
| SCHEMBL6597332 | 0.74 | MMP2 (0.65) | ADAM17MMP2MMP9 | |
| SCHEMBL7430037 | 0.73 | ADAM17 (0.75) | ADAM17MMP2MMP9 | |
| SCHEMBL6633286 | 0.73 | SMN1; SMN2 (0.47) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL6598735 | 0.72 | ADAM17 (0.70) | ADAM17MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263756-A2 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | Bristol-Myers Squibb Pharma Company (US) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001070734-A2 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |