Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2J2 | P51589 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 3/20 | 0.46 |
| ▸ | HRH2 | P25021 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401016 | 0.73 | DRD2 (0.66) | DRD2SLC6A4 | |
| SCHEMBL7453229 | 0.72 | HDAC1 (0.48) | HRH1HRH2KMT2ADRD2DRD3 | |
| SCHEMBL7450601 | 0.72 | HDAC1 (0.48) | HRH1HRH2KMT2ADRD2DRD3 | |
| SCHEMBL7445946 | 0.72 | HDAC1 (0.48) | HRH1HRH2KMT2ADRD2DRD3 | |
| SCHEMBL7402278 | 0.71 | DRD2 (0.50) | KMT2ADRD2 | |
| SCHEMBL15988693 | 0.70 | LMNA (0.70) | KMT2ATBXAS1 | |
| SCHEMBL7450828 | 0.69 | HDAC1 (0.50) | HRH1HRH2KMT2ADRD2DRD3 | |
| SCHEMBL7447765 | 0.69 | HDAC1 (0.50) | HRH1HRH2KMT2ADRD2DRD3 | |
| SCHEMBL7447775 | 0.69 | HDAC1 (0.50) | HRH1HRH2KMT2ADRD2DRD3 | |
| SCHEMBL7446680 | 0.68 | HTR1A (0.47) | HRH1HRH2KMT2ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5206233-A | Antidepressants, antiischemic agents | WARNER-LAMBERT COMPANY (US) | 1993-04-27 | — | — | US | claimed |
| WO-1993004053-A1 | SUBSTITUTED THIAZEPINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-04 | — | — | WO | claimed |
| US-5206233-A | Antidepressants, antiischemic agents | WARNER-LAMBERT COMPANY (US) | 1993-04-27 | — | — | US | disclosed |
| WO-1993004053-A1 | SUBSTITUTED THIAZEPINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-04 | — | — | WO | disclosed |