Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.42 |
| ▸ | HRH1 | P35367 | 6/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740661 | 0.89 | P2RX7 (0.41) | TP53KMT2AMEN1 | |
| SCHEMBL740662 | 0.89 | P2RX7 (0.41) | TP53KMT2AMEN1 | |
| SCHEMBL739857 | 0.85 | HRH1 (0.57) | KCNH2HRH1CYP2D6CHRM1USP2 | |
| SCHEMBL740437 | 0.83 | HRH1 (0.38) | KCNH2HRH1CYP2D6CHRM1HSD11B1 | |
| SCHEMBL740436 | 0.83 | HRH1 (0.38) | KCNH2HRH1CYP2D6CHRM1HSD11B1 | |
| SCHEMBL740778 | 0.82 | MMEL1 (0.38) | KCNH2HRH1CYP2D6CHRM1HSD11B1 | |
| SCHEMBL739361 | 0.82 | HRH1 (0.35) | KCNH2HRH1CYP2D6CHRM1HSD11B1 | |
| SCHEMBL739667 | 0.81 | KCNH2 (0.43) | KCNH2HRH1CYP2D6CHRM1TP53 | |
| SCHEMBL739144 | 0.81 | KCNH2 (0.38) | KCNH2HRH1CYP2D6CHRM1ALDH1A1 | |
| SCHEMBL739145 | 0.81 | KCNH2 (0.38) | KCNH2HRH1CYP2D6CHRM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |