Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 2/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL762625 | 1.00 | CYP2C9 (0.44) | CYP2C9KCNH2HRH1CYP2D6HPGDS | |
| SCHEMBL741974 | 0.89 | KCNH2 (0.52) | KCNH2HRH1CYP2D6HPGDSCHRM1 | |
| SCHEMBL741975 | 0.89 | KCNH2 (0.52) | KCNH2HRH1CYP2D6HPGDSCHRM1 | |
| SCHEMBL741439 | 0.88 | HRH1 (0.46) | KCNH2HRH1CYP2D6NLRP3CHRM1 | |
| SCHEMBL741679 | 0.85 | TRPV3 (0.41) | KCNH2HRH1CYP2D6HPGDSCHRM1 | |
| SCHEMBL741680 | 0.85 | TRPV3 (0.41) | KCNH2HRH1CYP2D6HPGDSCHRM1 | |
| SCHEMBL762594 | 0.85 | TRPV3 (0.43) | KCNH2HRH1CYP2D6HPGDSALOX5AP | |
| SCHEMBL742014 | 0.85 | HTT (0.43) | KCNH2HRH1CYP2D6CHRM1 | |
| SCHEMBL742013 | 0.85 | HTT (0.43) | KCNH2HRH1CYP2D6CHRM1 | |
| SCHEMBL765031 | 0.84 | P2RX3 (0.45) | KCNH2HRH1CYP2D6HPGDSCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |