Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 4/20 | 0.70 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | HPGD | P15428 | 4/20 | 0.66 |
| ▸ | CA12 | O43570 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.65 |
| ▸ | CA9 | Q16790 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12530914 | 0.88 | TSHR (0.72) | RAB9ALMNATP53ALDH1A1HPGD | |
| SCHEMBL25547142 | 0.87 | CA12 (0.83) | LMNACYP19A1TP53ALDH1A1HPGD | |
| SCHEMBL10463536 | 0.87 | CYP19A1 (0.68) | NPC1RAB9ALMNACYP19A1TP53 | |
| SCHEMBL28727051 | 0.86 | CYP19A1 (0.81) | NPC1RAB9ALMNACYP19A1ALDH1A1 | |
| SCHEMBL4919256 | 0.85 | HDAC6 (0.76) | LMNATP53ALDH1A1HPGDCA12 | |
| SCHEMBL20981410 | 0.85 | ALDH1A1 (0.68) | LMNATP53ALDH1A1HPGDCA12 | |
| SCHEMBL19358853 | 0.85 | TP53 (0.81) | LMNATP53ALDH1A1HPGDMAPT | |
| SCHEMBL7394036 | 0.85 | ALDH1A1 (0.77) | NPC1RAB9ALMNACYP19A1TP53 | |
| SCHEMBL7396831 | 0.84 | LMNA (0.63) | LMNATP53ALDH1A1HPGDCA12 | |
| SCHEMBL18727051 | 0.84 | CA12 (0.68) | RAB9ALMNACYP19A1TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703749-B2 | Compositions and methods for treating Friedreich's Ataxia | FRATAGENE THERAPEUTICS S.R.L. (IT) | 2014-04-22 | — | — | US | disclosed |
| US-20130109658-A1 | COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | FRATAGENE THERAPEUTICS S.R.L. (IT) | 2013-05-02 | — | — | US | disclosed |
| US-5753659-A | ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, | ZENECA LIMITED (GB) | 1998-05-19 | — | — | US | disclosed |
| US-5750754-A | TERTIARY BUTYL 3-METHYL-4-SUBSTITUTED BUTYRATE; CHEMICAL INTERMEDIATES FOR ANTICAOGULANT DRUGS | ZENECA LIMITED (GB) | 1998-05-12 | — | — | US | disclosed |
| US-5563141-A | INHIBIT CELL ADHESION FOR EXAMPLE, PLATELET AGGRE GATION | ZENECA LIMITED (GB) | 1996-10-08 | — | — | US | disclosed |
| EP-0690847-A1 | HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | ZENECA LIMITED (GB) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994022835-A2 | HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | ZENECA LIMITED (GB) | 1994-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109658-A1 | COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | ATXN2, ATXN2L, ATXN10 | NPC1 110/4885RAB9A 3124/4885LMNA 276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.