Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.60 |
| ▸ | NAMPT | P43490 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7403303 | 0.87 | NPC1 (0.72) | CYP19A1MEN1KMT2ATP53POLB | |
| SCHEMBL1287408 | 0.87 | TSHR (0.68) | CYP19A1MEN1KMT2ATP53POLB | |
| SCHEMBL1169525 | 0.86 | POLB (0.65) | CYP19A1MEN1KMT2ATP53POLB | |
| SCHEMBL28727051 | 0.85 | CYP19A1 (0.81) | CYP19A1ALDH1A1NPC1RAB9ATSHR | |
| SCHEMBL4413173 | 0.82 | SMN1; SMN2 (0.68) | CYP19A1ALDH1A1HSD17B10NAMPTNPC1 | |
| SCHEMBL27348643 | 0.82 | ALDH1A1 (0.59) | CYP19A1MEN1KMT2ATP53POLB | |
| SCHEMBL1287434 | 0.81 | ALDH1A1 (0.70) | CYP19A1MEN1KMT2ATP53POLB | |
| SCHEMBL6271065 | 0.81 | ALDH1A1 (0.66) | CYP19A1MEN1KMT2ATP53POLB | |
| SCHEMBL5960116 | 0.81 | MEN1 (0.73) | CYP19A1MEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL10205710 | 0.81 | ALDH1A1 (0.66) | CYP19A1MEN1KMT2ATP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703749-B2 | Compositions and methods for treating Friedreich's Ataxia | FRATAGENE THERAPEUTICS S.R.L. (IT) | 2014-04-22 | — | — | US | disclosed |
| US-20130109658-A1 | COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | FRATAGENE THERAPEUTICS S.R.L. (IT) | 2013-05-02 | — | — | US | disclosed |
| US-4948809-A | TREATMENT OF AILMENTS DUE TO THROMBOCYTE AGGREGATION OR KIDNEY DYSFUNCTION | BOEHRINGER MANNHEIM GMBH (DE) | 1990-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109658-A1 | COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | ATXN2, ATXN2L, ATXN10 | CYP19A1 3647/4885MEN1 3597/4885KMT2A 1775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.