Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.60 |
| ▸ | ITGAV | P06756 | 19/20 | 0.60 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.50 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.45 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5027067 | 1.00 | ITGB3 (0.60) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL6111422 | 1.00 | ITGB3 (0.60) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL7401335 | 0.98 | ITGB3 (0.59) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL7401332 | 0.98 | ITGB3 (0.59) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL13059980 | 0.94 | ITGB3 (0.54) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL7401929 | 0.89 | ITGB3 (0.47) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| Iodide SCHEMBL7403599 | 0.85 | ITGB3 (0.49) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL7346806 | 0.84 | ITGB3 (0.61) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL5022907 | 0.84 | ITGB3 (0.61) | ITGB3ITGAVITGA2BITGB5ITGB6 | |
| SCHEMBL8643210 | 0.84 | ITGB3 (0.59) | ITGB3ITGAVITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828737-A1 | ISOXAZOLINE AND ISOXAZOLE DERIVATIVES AS INTEGRIN RECEPTOR ANTAGONISTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996037492-A1 | ISOXAZOLINE AND ISOXAZOLE DERIVATIVES AS INTEGRIN RECEPTOR ANTAGONISTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-11-28 | — | — | WO | disclosed |