Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 13/20 | 0.49 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | F7 | P08709 | 1/20 | 0.47 |
| ▸ | F3 | P13726 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.40 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247707 | 0.88 | F2 (0.60) | TPSAB1F2F7F3PRSS1 | |
| SCHEMBL8205180 | 0.87 | TPSAB1 (0.52) | TPSAB1F2F7F3PRSS1 | |
| SCHEMBL5885589 | 0.84 | F2 (0.59) | TPSAB1F2F7F3PRSS1 | |
| SCHEMBL7021913 | 0.83 | F2 (0.42) | TPSAB1F2F7F3PRSS1 | |
| SCHEMBL7023919 | 0.83 | TPSAB1 (0.47) | TPSAB1F2F7F3PRSS1 | |
| SCHEMBL7694668 | 0.83 | TPSAB1 (0.47) | TPSAB1F2F7F3PRSS1 | |
| SCHEMBL7020466 | 0.82 | TPSAB1 (0.43) | TPSAB1F2F7F3PRSS1 | |
| SCHEMBL7029085 | 0.82 | TPSAB1 (0.43) | TPSAB1F2F7F3PRSS1 | |
| SCHEMBL7018545 | 0.82 | TPSAB1 (0.43) | TPSAB1F2F7F3PRSS1 | |
| SCHEMBL7140320 | 0.82 | F2 (0.47) | TPSAB1F2F7F3PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900207-B1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-0900207-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 1999-03-10 | — | — | EP | disclosed |
| US-5866573-A | Pyrazinone thrombin inhibitors | MERCK & CO., INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1997040024-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1997-10-30 | — | — | WO | disclosed |