Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | F7 | P08709 | 1/20 | 0.47 |
| ▸ | F3 | P13726 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 11/20 | 0.46 |
| ▸ | PLAU | P00749 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247707 | 0.86 | F2 (0.60) | F2F7F3PRSS1TPSAB1 | |
| SCHEMBL3240576 | 0.86 | MEN1 (0.44) | PLAUMEN1KMT2A | |
| SCHEMBL3247710 | 0.84 | P2RX7 (0.43) | F2F7F3PRSS1TPSAB1 | |
| SCHEMBL7141645 | 0.84 | HSD17B10 (0.43) | F2F7F3PRSS1TPSAB1 | |
| SCHEMBL5885589 | 0.83 | F2 (0.59) | F2F7F3PRSS1TPSAB1 | |
| SCHEMBL8205180 | 0.82 | TPSAB1 (0.52) | F2F7F3PRSS1TPSAB1 | |
| SCHEMBL7020342 | 0.82 | F2 (0.40) | F2F7F3PRSS1TPSAB1 | |
| SCHEMBL7912621 | 0.82 | TPSAB1 (0.61) | F2F7F3PRSS1TPSAB1 | |
| SCHEMBL7403728 | 0.82 | TPSAB1 (0.49) | F2F7F3PRSS1TPSAB1 | |
| SCHEMBL7456341 | 0.82 | TPSAB1 (0.48) | F2F7F3PRSS1TPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506761-B1 | Compound of the invention are active as inhibitors of Thrombin and are useful in treating disease states in mammals which are characterized by abnormal thrombosis and have the following structure: | CORVAS INTERNATIONAL, INC. | 2003-01-14 | — | — | US | disclosed |
| US-6506760-B1 | Compounds of the invention are active as inhibitors of Thrombin and are useful in treating disease states in mammals which are characterized by abnormal thrombosis and have the following structure: | CORVAS INTERNATIONAL, INC. | 2003-01-14 | — | — | US | disclosed |
| WO-2001079193-A2 | SUBSTITUTED HYDRAZINYL HETEROAROMATIC INHIBITORS OF THROMBIN | CORVAS INTERNATIONAL, INC. (US) | 2001-10-25 | — | — | WO | disclosed |